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We found that, as with folate deficiency (which may effectively alter methylation reactions and deoxyribonucleotide biosynthesis), methionine loading (which maintains an efficient transmethylation pathway) promotes the occurrence of an oxidant stress-mediated prethrombotic state that is correlated with total plasma homocysteine concentration (Durand et al, 1997a

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Br J Dermatol 155:18 Krengel S, Scope A, Dusza SW et al (2013) New recommendations for the categorization of cutaneous features of congenital melanocytic nevi